SUCCESSFUL PERIOPERATIVE COMBINATION OF HIGH-DOSE FVIII THERAPY FOLLOWED BY EMICIZUMAB IN A PATIENT WITH HEMOPHILIA A WITH INHIBITORS

Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors

We managed perioperative hemostasis for a 72-year-old man with hemophilia A and low inhibitor titers (3 BU/mL), who underwent osteosynthesis for supracondylar fracture of the left humerus.He was treated perioperatively using the combination of high doses of factor VIII (FVIII) with recombinant human Factor VIII Fc fusion protein (rFVIIIFc), followe

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Calcium Signals from the Vacuole

The vacuole is by far the largest intracellular Ca2+ store in most plant cells.Here, the current knowledge about Board Game the molecular mechanisms of vacuolar Ca2+ release and Ca2+ uptake is summarized, and how different vacuolar Ca2+ channels and Ca2+ pumps may contribute to Ca2+ signaling in plant cells is discussed.To provide a phylogenetic pe

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